Pharmaceutical Process

For companies involved in pharmaceutical manufacturing, the challenges of regulatory compliance and ensuring safety are numerous. Precise temperature control is crucial for effective process cooling and cold storage. In the pharmaceutical industry, strict adherence to conditions and critical parameter maintenance are essential at every process stage.

Room temperature, typically 20°C to 25°C, is the setting for many pharmaceutical activities. However, certain drug substances that degrade under room-temperature conditions require cold storage, ranging from 8°C to 15°C. Furthermore, highly degradable drugs, vitamins, and chemicals necessitate cold storage conditions ranging from 2°C to 8°C. Lowering the temperature can significantly slow chemical reactions and microbial growth.

Fridge storage, on the other hand, involves temperatures between -4°C and 2°C. As these stored goods often include high-value products, maintaining a precise temperature range becomes critical due to their sensitivity to temperature fluctuations. The loss of refrigeration can result in substantial monetary losses, production and supply chain disruptions, and stock losses.

Companies turn to CO2, Ammonia refrigeration, and alternative refrigerants to address these challenges. Custom industrial refrigeration systems are designed to meet the specific process requirements for the cold storage of pharmaceuticals. Pharmaceutical companies utilise cold storage warehouses to safeguard syrups and injections from denaturation. These facilities incorporate state-of-the-art control and monitoring equipment, ensuring a temperature-controlled and climate-controlled environment. Cold temperatures are vital in preventing the contamination of pharmaceutical materials from being compromised.

The refrigerants commonly used in most cold storage facilities include ammonia (NH3), carbon dioxide (CO2), and HFC/HFO compounds. Ammonia is the predominant refrigerant used in large-scale food and beverage refrigeration systems. However, CO2 refrigerant has become the preferred choice for facilities with freezer applications due to its exceptional performance at low temperatures.